The susceptibility to obesity, a condition known as Sthoulya in Ayurveda which is caused by imbalances in fat metabolism (Medoroga), varies significantly among individuals, particularly in urban communities. This condition has negative impacts on both the body and mind. Consequently, it has been declared a global epidemic by the World Health Organization (W.H.O.), leading to the term 'Globesity'. The rapid increase in the prevalence of obesity makes it necessary for healthcare professionals from various disciplines to thoroughly understand its fundamental causes. They should do so based on fundamental principles of individual health sciences. Also, in order to meet the global demand, they should provide effective management techniques, whether pharmacologic or non-pharmacologic. Ayurveda, a natural and holistic health discipline, is eagerly anticipated to control and prevent obesity.The world is eagerly awaiting successful control and prevention of obesity through Ayurveda, a natural and holistic health science. With these considerations in mind, this paper aims to explore the causes (Nidāna), pathogenesis (Saṃprāpti), and treatment strategies (Cikitsa Sutra) for Sthoulya, while also drawing connections to the etio-pathogenesis of obesity. Additionally, it presents some noteworthy clinical experiences that can contribute to the betterment of mankind.