Background: Saffron, a natural substance, has been traditionally used for centuries to address a range of disorders. It is obtained from the dried stigmas of the Crocus sativus plant, belonging to the Iridaceae family.

Objective: To explore the role of saffron in preventing and managing non-communicable diseases (NCDs).

Methods: By exploring Unani classical books, NCBI articles, PubMed, Google Scholar, etc.

Results: The results illustrated the role of Za‘frān as Dāfi‘-i-Tashannuj (anti-spasmodic), Dāfi‘-i-Maraḍ-i-Alzhā’imar (anti-alzheimer), Dāfi‘-i-Afsurdagī (anti-depressant), Dāfi‘-i-Siman Mufriṭ (anti-obesity), hypoglycemic and Dāfi‘-i-Maraḍ Dhayābīṭus (anti-diabetic) effects, besides other functions.

Conclusion: This study suggests that saffron, due to its diverse medicinal benefits, could play a significant role in the prevention and management of non-communicable diseases.