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Abstract

Indian Journal of Modern Research and Reviews, 2026; 4(5): 222-227

Investigating the Predictive Role of Leptin–Adiponectin Imbalance in Polycystic Ovary Syndrome Among Overweight Iraqi Females

Author Name: Wesam Hassan Ali Ali, Mohammed Noaman Alanssari, Ammar M.

1. Food Science, Agriculture Faculty, University of Kufa, Najaf, Iraq

2. Department of Chemistry, Faculty of Education, University of Kufa, Al-Najaf, Iraq

3. Department of Chemistry, College of Science, University of Kufa, Najaf, Iraq

Abstract

<p>The polycystic ovary syndrome (PCOS) chain reaction (PCC) is a hormonal enhancement factor closely associated with metabolic disorders. The adenokines leptin and adiponectin play a key role in regulating insulin activity. They also have a reproductive function through fat absorption, and the regulation of their transport may contribute to the development of PCC. This is an additional type of &quot;lipid control,&quot; characterised by elevated leptin and adiponectin levels in the blood of 120 Iraqi men aged 18&ndash;44 years, including 60 adult men and 60 men over 60. Control groups of men and women were also included. Long menstrual cycles of 2&ndash;5 days were analysed, and biochemical markers were measured using spectroscopy. In patients with polycystic ovary syndrome (PCOS), leptin flow is significantly increased, and excess fat is transported via this pathway. A control group was also analysed (<em>P</em>&lt;0.05). Enhanced leptin/adiponectin exhibits high diagnostic power, with an area under the curve (AUC) of 0.80 (80%) and a specificity score of 73% (0.03%). Leptin shows strong positive affinity for carotid intima-media thickness (IMT), triglycerides, and leptin protein (LPD), indicating a positive correlation with metabolic processes associated with diabetes. These results demonstrate that adiponectin&#39;s nutritional balance plays a role in metabolic and reproductive processes, as evidenced by its excellent function and superactive protein (SPC) activity. This enhanced leptin/adiponectin activity is an important biomarker for promoting health.</p>

Keywords

Adiponectin, Adipokines, Leptin, Polycystic Ovarian Syndrome (PCOS)