<p>Artificial Intelligence (AI) is increasingly transforming healthcare through predictive analytics, machine learning, clinical decision support systems, and digital health technologies. Women&#39;s healthcare, particularly in obstetrics and gynaecology, has witnessed substantial advancements through AI-assisted diagnosis, pregnancy monitoring, fertility management and disease prediction. Simultaneously, Ayurveda provides a holistic and personalized approach to women&#39;s health through the principles of Prasuti Tantra and Stree Roga. The integration of AI with Ayurvedic healthcare offers opportunities to strengthen individualized treatment, improve clinical research methodologies, and generate evidence-based healthcare solutions. AI-based technologies can facilitate Prakriti assessment, pregnancy risk prediction, patient stratification, treatment outcome analysis, and real-world evidence generation. In clinical research, AI has the potential to improve participant recruitment, data management, predictive modelling and healthcare analytics. Despite these opportunities, challenges remain regarding standardization, data quality, ethical considerations, algorithmic bias, and integration of traditional medical knowledge with modern computational approaches. This review examines the role of artificial intelligence in Prasuti Tantra and Stree Roga, explores its applications in clinical research, discusses opportunities and limitations, and highlights future directions for integrating Ayurveda and AI in women&#39;s healthcare. The convergence of these disciplines may contribute significantly to precision medicine and evidence-based Ayurvedic practice.</p>