The polycystic ovary syndrome (PCOS) chain reaction (PCC) is a hormonal enhancement factor closely associated with metabolic disorders. The adenokines leptin and adiponectin play a key role in regulating insulin activity. They also have a reproductive function through fat absorption, and the regulation of their transport may contribute to the development of PCC. This is an additional type of "lipid control," characterised by elevated leptin and adiponectin levels in the blood of 120 Iraqi men aged 18–44 years, including 60 adult men and 60 men over 60. Control groups of men and women were also included. Long menstrual cycles of 2–5 days were analysed, and biochemical markers were measured using spectroscopy. In patients with polycystic ovary syndrome (PCOS), leptin flow is significantly increased, and excess fat is transported via this pathway. A control group was also analysed (P<0.05). Enhanced leptin/adiponectin exhibits high diagnostic power, with an area under the curve (AUC) of 0.80 (80%) and a specificity score of 73% (0.03%). Leptin shows strong positive affinity for carotid intima-media thickness (IMT), triglycerides, and leptin protein (LPD), indicating a positive correlation with metabolic processes associated with diabetes. These results demonstrate that adiponectin's nutritional balance plays a role in metabolic and reproductive processes, as evidenced by its excellent function and superactive protein (SPC) activity. This enhanced leptin/adiponectin activity is an important biomarker for promoting health.
Adiponectin, Adipokines, Leptin, Polycystic Ovarian Syndrome (PCOS)
. Investigating the Predictive Role of Leptin–Adiponectin Imbalance in Polycystic Ovary Syndrome Among Overweight Iraqi Females. Indian Journal of Modern Research and Reviews. 2026; 4(5):222-227
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